B12 Deficiency Support Group
Your health - Your voice - Your choice.
Supporting the fight to access diagnosis and personalised treatment.
Research Articles - click on each individual description to access the article...
In presenting the Nobel Prize in 1934 to Minot, Murphy, and Whipple, Israel Holmgren of the Karolinska Institute paid them the ultimate compliment that can be bestowed upon a physician: "This new method . . . has already saved thousands of lives, and will in the future save innumerable human beings from death. (Click here to access the full article)
B12 IS NOT TOXIC. Safety of B12 (Click here to access the full article)
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An important announcement regarding reliability of b12 serum assay tests. (Click here for access to full article,)
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Research evidence for increased need of injections. (Click here for access to the article - click on the first article that appears in the pop up window)
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This article suggests that functional signs and symptoms of b12 deficiency can occur at ANY serum level (Click here for the article)
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Macrocytic megaloblastic anemia is the most typical but the latest sign of a cobalamin (vitamin B12) and/or folic acid deficiency (Click here for the article)
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On 5’-deoxyadenosylcobalamin and methylcobalamin as sources for Vitamin B12 added as a nutritional substance in food supplements -- interesting article about b12 in food - and clear explanations about safety of b12 and general info about b12 (click here for the article)
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Traditional reference values for serum vitamin B12 and folate are not applicable to automated serum vitamin B12 and folate assays: comparison of value from three automated serum vitamin B12 and folate assays (click here for the article)
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A B12 of 100-400pg/ml is equivocal and prompts testing for MMA and homocysteine... (Page 471 Endocrine and Metabolic Disorders: Clinical Lab Testing Manual, Fourth Edition By Robert F. Dons, Frank H. Wians, Jr)(click here to access the article)
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'Goodkin et al. suggest that cobalamin deficiency be assessed by increased serum homocysteine and methylmalonate levels,
as elevation in one of these tests would mean a true state of significant cobalamin deficiency'........and this bit ...'Herbert felt that the neurologic effects of vitamin B12 deficiency are likely due to homocysteine toxicity.Steiner et al. postulated that some of the neurologic damage is secondary to an autoimmune neuronal demyelinization.Dommisse felt that a possible cause of mood disorders due to vitamin B12 deficiency is axonal degeneration and nerve-sheath demyelination, especially in the median forebrain bundle area.Shorvon et al. found that peripheral neuropathy was the most common neurologic manifestation4 and that it occurred in 40% of vitamin B12-deficient patients. The only mental status abnormalities noted by Addison in his description of pernicious anemia were delirium and confusion.
For the full article click here