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Research Articles - click on each individual description to access the article...

 

In presenting the Nobel Prize in 1934 to Minot, Murphy, and Whipple, Israel Holmgren of the Karolinska Institute paid them the ultimate compliment that can be bestowed upon a physician: "This new method . . . has already saved thousands of lives, and will in the future save innumerable human beings from death. (Click here to access the full article)

B12 IS NOT TOXIC. Safety of B12 (Click here to access the full article)

 

 

 

 

 

 

 

 

  • 'Goodkin et al. suggest that cobalamin deficiency be assessed by increased serum homocysteine and methylmalonate levels,

as elevation in one of these tests would mean a true state of significant cobalamin deficiency'........and this bit ...'Herbert felt that the neurologic effects of vitamin B12 deficiency are likely due to homocysteine toxicity.Steiner et al. postulated that some of the neurologic damage is secondary to an autoimmune neuronal demyelinization.Dommisse felt that a possible cause of mood disorders due to vitamin B12 deficiency is axonal degeneration and nerve-sheath demyelination, especially in the median forebrain bundle area.Shorvon et al. found that peripheral neuropathy was the most common neurologic manifestation4 and that it occurred in 40% of vitamin B12-deficient patients. The only mental status abnormalities noted by Addison in his description of pernicious anemia were delirium and confusion.

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